Yaniari Sulis Hasanah. B4109516. Jurusan Kesehatan, Program Studi Gizi Klinik, Politeknik Negeri Jember. Pengaruh Pemberian Sari Daun Seledri Terhadap Penurunan Kadar Gula Darah Sewaktu Mencit Hiperglikemik. Komisi Pembimbing, Ketua: dr. Arisanty Nur Setia R, Anggota: Ir. Heri Warsito, MP.

Hasanah, Yaniari Sulis (2013) Yaniari Sulis Hasanah. B4109516. Jurusan Kesehatan, Program Studi Gizi Klinik, Politeknik Negeri Jember. Pengaruh Pemberian Sari Daun Seledri Terhadap Penurunan Kadar Gula Darah Sewaktu Mencit Hiperglikemik. Komisi Pembimbing, Ketua: dr. Arisanty Nur Setia R, Anggota: Ir. Heri Warsito, MP. Undergraduate thesis, Politeknik Negeri Jember.

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Abstract

BACKGROUND : Diabetes mellitus is a collection of symptoms that occur in the aspect of a person caused by an increase in blood sugar levels (hyperglycemia) due to insulin deficiency (Badawi, 2009). One of the medicinal plants that can be used as a folk remedy for diabetes mellitus is celery (Apium graveolens L.). Empirically celery is a plant that can be used to treat diabetes mellitus . Celery mechanism in lowering blood sugar levels because it has an active ingredient that can lower blood sugar levels , among others : the flavonoid compounds apiin. Apiin is the main active substance contained in the celery plant (Arief , 2006). Apiin compound works to stimulate pancreatic beta cells and the time consumed by people with diabetes mellitus will be heading to the adipose tissue and striated muscle, which will enable existing phosphorylation in adipose tissue and skeletal muscle. Phosphorylation stimulates insulin secretion in the patent . So the sugar get into the cells by passive diffusion pancreatic β, which mediated the specific membrane protein (glucose transporter 2). While the sugar into the plasma membrane through which the sugar transporter 4 can also stimulate the secretion of insulin. Because of the insulin secretion of the hormone insulin then productivity can be increased. Automatically decreases the production of sugar by the liver and blood sugar levels can be decreased (Winarto, 2003).

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