Pengaruh Pemberian Kombinasi Minuman Oatmeal Dengan Bubuk Cokelat Terhadap Kadar LDL Tikus Galur Wistar (Rattus Novergicus ) Diabetes Mellitus

Hanifah, Hanifah (2024) Pengaruh Pemberian Kombinasi Minuman Oatmeal Dengan Bubuk Cokelat Terhadap Kadar LDL Tikus Galur Wistar (Rattus Novergicus ) Diabetes Mellitus. Undergraduate thesis, Politeknik Negeri Jember.

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Abstract

Diabetes melitus yang tidak terkontrol dengan baik akan menyebakanterjadinya komplikasi salah satunya adanya gangguan pada profil lipid. Mengonsumsi produk minuman tinggi serat yaitu minuman oatmeal dapat membantu menurunkan kadar LDL dalam keadaan DM. Tujuan penelitian untuk mengetahui pengaruh pemberian kombinasi minuman oatmeal terhadap kadar LDL tikus galur wistar (rattus novergicus) diabetes mellitus. Jenis penelitian true- exsperimental dengan desain pretest-posttest with controlgroup. Penelitian menggunakan 30 ekor tikus wistar jantan usia 2-3 bulan dengan berat badan 150-200 gram yang dibagi menjadi lima kelompok, yaitu kelompok kontrol negatif (K-) diberi pakan standart comfeed AD II 20 g/hari,kelompok (K+) diberi pakan standart comfeed AD II 20 g//hari+stz+HFD 4 ml/hari, kelompok perlakuan satu (P1) diberi pakan standart comfeed AD II 20g/hari+stz+HFD 4 ml/hari, kelompok perlakuan dua (P2) diberikan pakan standartcomfeed AD II 20g/hari+stz+minuman oatmeal 4 ml+HFD 1 ml+ obat glimepirid 1 ml/hari, dan kelompok perlakuan tiga (P3) diberi pakan standart comfeed AD II 20g/hari+stz +HFD 4 ml+ obat glimepirid 1 ml/hari selama 14 hari. Hasil penelitian menunjukkan kadar LDL sebelum dan setelah intervensi tidak terdapat perbedaan yang signifikan pada kelompok kontrol negatif (p = 0,752), kelompok kontrol positif (p=1,000), kelompok perlakuan tiga (p=0,797) dan terdapat perbedaan signifikan pada kelompok perlakuan satu (p = 0,019), dan kelompok perlakuan dua (p = 0,004). Hasil uji selisih perbedaan kadar LDL pretest dan posttest tidak terdapat perbedaan yang signifikan antar kelompok kontrol negatif, kontrol positif, dan perlakuan (P1,P2,P3) (p = 0,197). Tidak terdapat pengaruh pemberian minuman oatmeal terhadap kadar LDL tikus galur wistar diabetes mellitus tetapi terdapat pengaruh pemberian minuman oatmeal terhadap kadar LDL tikus galur wistar diabetes mellitus pada perlakuan kedua. Diabetes mellitus that is not well controlled will cause complications, one of which is disturbances in the lipid profile. Consuming high fiber beverage products, namely oatmeal drinks, can help reduce LDL levels in DM conditions. The aim of the research was to determine the effect of giving a combination of oatmeal drinks on the LDL levels of Wistar rats (rattus novergicus) with diabetes mellitus. This type of research is true-experimental with a pretest-posttest design with control group. The research used 30 male Wistar rats aged 2-3 months with a body weight of 150-200 grams which were divided into five groups, namely the negative control group (K-) given standard AD II comfeed 20 g/day, the group (K+) given standard feed standard comfeed AD II 20 g//day +stz+HFD 4 ml/day, treatment group one (P1) was given standard comfeed AD II 20 g/day+stz+HFD 4 ml/day, treatment group two (P2) was given standard comfeed AD II feed 20 g/day+stz+oatmeal drink 4 ml+HFD 1 ml+ glimepiride drug 1 ml/day, and treatment group three (P3) was given standard comfeed AD II feed 20 g/day+stz +HFD 4 ml+ glimepirid 1 ml/day for 14 days. The results showed that there was no significant difference in LDL levels before and after the intervention in the negative control group (p = 0.752), positive control group (p = 1.000), treatment group three (p = 0.797) and there was a significant difference in treatment group one ( p = 0.019), and treatment group two (p = 0.004). The results of the difference test between pretest and posttest LDL levels showed no significant differences between the negative control, positive control and treatment groups (P1, P2, P3) (p = 0.197). There was no effect of giving oatmeal drinks on the LDL levels of Wistar rats with diabetes mellitus, but there was an effect of giving oatmeal drinks on LDL levels of Wistar rats with diabetes mellitus in the second treatment.

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