Pengaruh Pemberian Cookies Kedelai Kunyit Zaitun Terhadap Kadar Low Density Lipoprotein Pada Tikus Jantan Galur Wistar Dislipidemia

Hapsari, Mutiara Amelia (2024) Pengaruh Pemberian Cookies Kedelai Kunyit Zaitun Terhadap Kadar Low Density Lipoprotein Pada Tikus Jantan Galur Wistar Dislipidemia. Diploma thesis, Politeknik Negeri Jember.

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Abstract

Dyslipidemia is a condition where abnormal lipid metabolism occurs, characterized by increased levels of total cholesterol, LDL, triglycerides, and decreased HDL. One of the efforts for dyslipidemia is through nonpharmacological therapy through nutritional therapy, namely the content of flavonoids which can inhibit cholesterol absorption and also activate LDL receptors (apo B-100). The product made is in the form of olive turmeric soy cookies. This study aims to determine the effect of giving olive turmeric soy cookies on LDL levels in dyslipidemic white mice. This research is a True Experimental type with a Pretest-Posttest Control Group Design approach. This study used 24 white rats, male, aged 2-3 months, body weight 150-250 grams, divided into 3 groups, namely group (K-) which was given standard feed, namely bio rats, group (K+) which was fed standard and high-fat feed, namely 2 grams of beef tallow, 1 gram of quail egg yolk, and 2 grams of butter, and group (P) was given standard feed, high-fat feed and olive turmeric soy cookies. Data were analyzed using the Kruskall Wallis, One Way Anova, Post Hoc, Man Whitney, and Wilcoxon tests. The results showed that there was no significant difference in pretest LDL levels (p = 0.437), there was a significant difference in posttest LDL levels (p = 0.011), there was a significant difference in pretest and posttest LDL levels in the (K+) group (p = 0.042) and the (P) (p = 0.042) while there was no significant difference in the (K-) group (p = 0.577), there was no difference in LDL levels between the control (K-) and treated (P) groups of mice. Giving olive turmeric soy cookies had no effect on reducing LDL levels in dyslipidemic white mice.

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