Soy and Dragon Fruit Functional Drink : The Potential to Reduce Cholesterol Total Levels in Hypercholesterolemic Sprague Dawley Rats

Suryana, Arinda Lironika and Putri, Chindy Yulita Krismuntiani and Rosiana, Nita Maria and Arum, Puspito (2024) Soy and Dragon Fruit Functional Drink : The Potential to Reduce Cholesterol Total Levels in Hypercholesterolemic Sprague Dawley Rats. International Journal of Health and Information System, 2 (1). pp. 49-56. ISSN 2987-4637

Text (Artikel Jurnal) 5. Dokumen Artikel_Arinda.pdf - Published Version Available under License Creative Commons Attribution Share Alike. Download (369kB)

Abstract

Hypercholesterolemia is a lipid metabolism disorder characterized by increased blood cholesterol levels. The alternative functional drinks that can reduce cholesterol levels are beverage ingredients that contain flavonoids, such asred dragon fruit and soybeans. Flavonoids can inhibit cholesterol synthesis by inhibiting the HMG-CoA reductase enzyme. Soybeans are also have a hypocholesterolemic effect because they contain isoflavones.This study aimedto determinedthe potential of soybean anddragon fruit peelpowder on the cholesterol levels of hypercholesterolemicSprague Dawley rats.This study wasa true-experimental design with a pretest -posttest with control group. The samples were 27 male Sprague Dawley rats, weighing 150-250 grams and aged 2 -3 months. The samples were divided into a control group and a treatment group that was given soybeans dragon fruit peel powder drink at a dose of 12.8 ml/kgBB/day for 14 days. Total cholesterol levels were measured using the CHOD–PAP method. Data were analyzed using the One Way Anova test, Post Hoc or Man Whitney test and Paired T-test.The results showed that there was a significant difference in total cholesterol levels in mice before and after the intervention (p= 0.003). Giving soybeans dragon fruit peels powder drink can significantly reduce total cholesterol levels in the treatment group (P) by 18.45% (p= 0.044).

Actions (login required)

View Item