Pengaruh Pemberian Snack Bar Tepung Gembili (Dioscorea esculenta) dan Tepung Kedelai (Glycine max) Terhadap Kadar Trigliserida Tikus Putih (Rattus novergicus) Hiperkolesterolemia

Rahmadani, Hardiyanti (2021) Pengaruh Pemberian Snack Bar Tepung Gembili (Dioscorea esculenta) dan Tepung Kedelai (Glycine max) Terhadap Kadar Trigliserida Tikus Putih (Rattus novergicus) Hiperkolesterolemia. Undergraduate thesis, Politeknik Negeri Jember.

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Abstract

Hypercholesterolemia is a condition of impaired cholesterol metabolism caused by increased cholesterol levels that exceed normal limits. Hypercholesterolemia can occur when the concentration of total cholesterol 240 mg/dl, LDL 160 mg/dl, and triglycerides 150 mg/dl. Increased levels of triglycerides in the blood can increase the risk of coronary heart disease and metabolic syndrome. Non-pharmacological therapy is done by providing intake of high-fiber nutrients that can reduce triglyceride levels in the blood. One of the high-fiber foods is a snack bar made of 90 g of gembili flour and 10 g of soybean flour which contains 7.16% fiber. The purpose of this study was to determine the effect of giving a snack bar made from gembili tubers and soybean flour as a combination of the use of the drug simvastatin on triglyceride levels in white rats (Rattus novergicus) hypercholesterolemia. This type of research is True experimental with Pretest-Posttest Control Group Design approach. The samples used in this study were white rats (Rattus novergicus) wistar strain with male sex totaling 18, 2-3 months old and weighing 150-250 g which were divided into 3 groups, namely the negative control group (K-), positive control (K+), and treatment (P). The design in this study used the Pretest-Posttest with Control Group Design. The negative control group (K-) was only given standard feed. The positive control group (K+) was given a diet high in fat, 0.01% PTU and a standard diet. While the treatment group (P) was given a diet high in fat, 0.01% PTU, snack bar and standard feed. The results showed that there was no difference in triglyceride levels before and after the intervention in the negative control group (p = 0.893), positive control (p = 0.116), and treatment (p = 0.345). So it can be concluded that there is effect of giving gembili flour and soybean flour snack bars on triglyceride levels in white rats (Rattus novergicus) hypercholesterolemia.

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