Pengaruh Pemberian Snack Bar Tepung Gembili (Dioscorea Esculenta) dan Tepung Kedelai (Glycine Max) terhadap Kadar Kolesterol Total Tikus Putih (Rattus Novergicus) Dislipidemia

Sa'ida, Ani Nur (2021) Pengaruh Pemberian Snack Bar Tepung Gembili (Dioscorea Esculenta) dan Tepung Kedelai (Glycine Max) terhadap Kadar Kolesterol Total Tikus Putih (Rattus Novergicus) Dislipidemia. Undergraduate thesis, Politeknik Negeri Jember.

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Abstract

Dyslipidemia is a fat metabolism disorder characterized by an increase or decrease in the fat fraction in plasma, one of which is an increase in total cholesterol levels. Non-pharmacological therapy that can be done is by providing high-fiber nutritional intake that can reduce cholesterol levels in the blood. One of the high-fiber foods is a snack bar made with 90 grams of gembili tubers and 10 grams of soy flour which contains 7.16% fiber. The purpose of this study was to determine the effect of giving a snack bar made with the basic ingredients of gembili tubers and soybean flour as a combination of the use of the drug simvastatin on reducing total cholesterol levels in dyslipidemic white rats (Rattus norvegicus) Wistar strainThis type of research is True experimental with Pretest-Posttest Control Group Design approach. This study used 18 rats aged 2-3 months weighing 150-250 grams which were divided into 3 groups, namely negative control, positive control, and treatment. The negative control group was only given standard feed. The positive control group was given quail egg yolk, 0.01% PTU and standard feed. While the treatment group was given quail egg yolk, 0.01% PTU, snack bar and standard feed. The results showed that there was no difference in cholesterol levels before and after the intervention in the negative control (p = 0.336), positive control (p = 0.090) and treatment group (p = 0.525). So, it can be concluded that there is no effect of giving gembili flour and soybean flour snack bars to the cholesterol levels of dyslipidemic wistar rats.

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