PENGARUH PEMBERIAN MINUMAN “DELAI GAMA” TERHADAP KADAR TRIGLISERIDA TIKUS WISTAR YANG DIINDUKSI HIGH FAT DIET

Nuzulah, Salma Firdausi (2023) PENGARUH PEMBERIAN MINUMAN “DELAI GAMA” TERHADAP KADAR TRIGLISERIDA TIKUS WISTAR YANG DIINDUKSI HIGH FAT DIET. Undergraduate thesis, Politeknik Negeri Jember.

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Abstract

The habit of consuming excessive fatty foods can be a trigger for dyslipidemia. A person is said to have dyslipidemia if there is an increase or decrease in one or a combination of blood lipid fractions, one of which is an increase in triglyceride levels. High triglyceride levels can be reduced by non-pharmacological therapy, namely the consumption of antioxidants. One of the antioxidants is vitamin C which is contained in a combination drink of soybean juice, red dragon fruit skin and honey. The purpose of this study was to determine the effect of giving a combination of soy sauce, red dragon fruit skin and honey on triglyceride levels of HFD-induced Wistar rats (2 ml of duck egg yolk, 10% lard, and 90% Comfeed AD-2 standard feed). The type of research is True Experimental with the Pretest-Posttest with Control Group Design approach. This study used 15 male Wistar rats which were divided into 3 groups, namely the negative control group (K-), namely the group that was given standard feed, the positive control group (K+), which was the group induced by high-fat feed and the treatment group (P), which was the group that induced by high-fat diet and intervention by drinking a combination of soybean extract, red dragon fruit skin and honey as much as 5 ml/day for 14 days. Examination of triglyceride levels was carried out using the spectrophotometric method. Data analysis used the Shapiro Wilk test, Kruskal Wallis, One Way Anova, and Paired T-Test. The results showed that there was no significant difference in rat triglyceride levels before the intervention (p=0.328), there was no significant difference in rat triglyceride levels after the intervention (p=0.289), there was no significant difference in rat triglyceride levels before and after the intervention (p= 0.839). So it was concluded that there was no effect of giving a combination drink of soybean extract, red dragon fruit skin and honey on triglyceride levels of HFD-induced Wistar rats.

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