Pemberian Minuman Soybeans Dragon Fruit Peel Powder Terhadap Kadar Kolesterol Total Tikus Sprague dawley Jantan Dislipidemia

Yulita Krismuntiani Putri, Chindy (2020) Pemberian Minuman Soybeans Dragon Fruit Peel Powder Terhadap Kadar Kolesterol Total Tikus Sprague dawley Jantan Dislipidemia. Undergraduate thesis, Politeknik Negeri Jember.

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Abstract

ABSTRACT Dyslipidemia is a disorder of lipid metabolism, one of which is an increase in total blood cholesterol levels which is more than 200 mg / dL. One alternative that can reduce total cholesterol of dyslipidemia sufferers is food that contains phenolic compounds (flavonoids), namely red dragon fruit and soybeans. Red dragon fruit contains flavonoids which can inhibit cholesterol synthesis by inhibiting the action of the HMG CoA reductase enzyme. Soybean is also believed to have hypocholesterolemia effect due to the presence of isoflavones. The purpose of this study was to determine the effect of the beverage soybeans dragon fruit peel powder on cholesterol levels of male Sprague dawley rats dyslipidemia. This type of research is true-experimental with pretest - posttest with control group design. This study used 27 male Sprague dawley strain rats with a body weight between 150-250 grams, aged 2-3 months. Rats were divided into 2 control groups and 1 treatment group that was given soybeans dragon fruit peel powder drink with a dose of 12.8 ml / kgBB / day for 14 days. Total cholesterol levels were measured by the CHOD-PAP (Cholesterol oxydase-phenyl aminopyrazolon) method. Data were analyzed with One Way Anova test followed by Post Hoc test or Man Whitney test and Paired T-test with the result there was a significant difference in total cholesterol levels of rats before and after the intervention. Giving soybeans dragon fruit peels powder drinks can reduce total cholesterol levels in the treatment group (P) by 18.45% significantly (p = 0,044).

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