Pengaruh Seduhan Kopi Biji Salak (Salacca Edulis Reinw) Terhadap Kadar Glukosa Darah 2 Jam Postprandial Tikus Diabetes Mellitus

Fathimiyah, Maghfirotul (2022) Pengaruh Seduhan Kopi Biji Salak (Salacca Edulis Reinw) Terhadap Kadar Glukosa Darah 2 Jam Postprandial Tikus Diabetes Mellitus. Diploma thesis, Politeknik Negeri Jember.

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Abstract

Salak Seed Coffee contains high levels of antioxidants. The content of flavonoids affects blood glucose 2 hours post prandial, there is a mechanism in inhibiting phosphodiesterase by preventing oxidative stress that causes complications in DM patients. The purpose of this study was to determine the effect of steeping salak coffee (Salacca edulis Reinw) on diabetic rats. This study used 24 male wistar rats with a body weight of 200-350 grams, aged 2-3 months. Rats were divided into 3 groups, a negative control group, a positive control group induced by streptozotocin, and a treatment group induced by streptozotocin and intervention with 4 ml of salak coffee beans for 14 days. Data were collected pretest and posttest by fasting for 2 hours after eating the mice and then taking blood through the orbital sinus of the eye. The results were analyzed by the Kruskal Wallis test, followed by the Mann-Whitney test. The test results of the treatment group had a median blood glucose level of 2 hours postprandial pretest of 209.5 mg/dL and posttest of 179 mg/dL had a significant value of p = 0.575 which means there is no significant difference between blood glucose levels 2 hours postprandial pretest and posttest . It can be concluded that there is no effect of steeping salak coffee beans on blood glucose levels 2 hours postprandial in diabetes mellitus rats before and after treatment. Keywords: Salak coffee beans, Blood Glucose Levels 2 Hours Post-Prandial, Antioxidants.

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